EP. - 3 Cannabis, Psychedelics and Brain Health with Dr. Manesh Girn – GBL TV

Episode 3 of Just Say KNOW with Maria Calabrese dives into the science and stigma surrounding psychedelics and cannabis with special guest Dr. Manesh Girn, a leading psychedelic neuroscientist. Together, they explore how substances like psilocybin and cannabis are transforming the future of mental health by enhancing neuroplasticity—the brain’s natural ability to adapt and heal.

In this episode, you’ll learn:

How psilocybin therapy works and why it’s showing promise in clinical research
The differences between cannabis compounds like THC, CBD, and CBG—and what they actually do
How these natural medicines may support emotional resilience, mental wellness, and personal growth

Dr. Girn also shares groundbreaking research from his work at UCSF and opens up about his own life-changing experiences with psilocybin that inspired his path in neuroscience. Whether you're curious, cautious, or completely new to this space, this episode will help you see these substances through a new, evidence-based lens.

Tune in, get informed, and Just Say KNOW.

Guests

Dr. Manesh Girn is a neuroscientist with a PhD from McGill University whose research explores how cannabis and psychedelics—particularly psilocybin—affect the brain and mental health. Currently a postdoctoral scholar at UCSF, he is at the forefront of investigating how these substances influence brain connectivity, neuroplasticity, and emotional well-being. Dr. Girn is passionate about making complex neuroscience accessible and is widely recognized for his work in both research and science communication.

Sources

🧠 Psychedelics & Neuroplasticity

Towards an Understanding of Psychedelic-Induced Neuroplasticity (Nature Neuroscience, 2022)
A comprehensive review exploring how psychedelics may enhance the brain’s ability to form new connections.
Psilocybin Desynchronizes the Human Brain (Nature, 2024)
Recent study showing how psilocybin alters brain connectivity patterns linked to mental health improvement.

🌱 Cannabis Compounds Explained (THC, CBD, CBG)

CBD vs. THC: What’s the Difference? (Healthline, 2023)
An accessible breakdown of the effects, benefits, and legal differences between CBD and THC.
What is the Difference between CBG vs. CBD? (Medical News Today, 2023)
A comparison of these non-intoxicating cannabinoids, highlighting their roles in wellness and therapeutic applications.

🧪 Therapeutic Research & Safety

Psychedelics and Neural Plasticity (BMC Neuroscience, 2023)
Explores how psychedelics like psilocybin impact brain rewiring and may support treatment for mood disorders.
Psilocybin and Antidepressant Effects in the Brain (PubMed, 2024)
Preclinical study showing how psilocybin promotes rapid and lasting antidepressant-like effects and supports neuroplasticity.

📊 Trends in Cannabis Consumption vs. Alcohol

Daily Marijuana Use Outpaces Daily Drinking in the U.S., Study Finds (PBS News Hour, May 2024)
Based on data spanning four decades, this Associated Press-reported study reveals that for the first time in U.S. history, daily or near daily marijuana use (17.7 million) has surpassed daily alcohol use (14.7 million). The findings highlight a major cultural and generational shift in substance use patterns, with cannabis increasingly preferred over alcohol-particularly among younger adults.
Cannabis Tops Alcohol in Daily Use for First Time Ever, Study Finds (Forbes, May 2024)
This article discusses the increasing prevalence of daily cannabis use over alcohol, highlighting a significant shift in consumption patterns among Americans.
Cannabis Is In and Alcohol Is Out: Is Gen Z Driving the Change in Preference? (CBS News, May 2024)
Exploring generational shifts, this piece examines how younger demographics, particularly those aged 18 to 24, are increasingly favoring cannabis over alcohol, with 69% preferring marijuana according to a 2022 survey.

🍺 Constellation Brands' Investment in Cannabis

Constellation Brands Converts Shares in Cannabis Operator Canopy, Departs Board (MJBizDaily, April 2024)
This article details Constellation Brands' decision to convert its shares in Canopy Growth and exit its board positions, reflecting changes in their cannabis investment strategy.

Resources

🎁 Bonus Resources from Dr. Manesh Girn

5 Steps to Re-Wiring Your Brain with Psychedelics – Free Guide (Dr. Manesh Girn, Psychedelic Insights)
A free downloadable guide that outlines simple, research-informed strategies for enhancing neuroplasticity and mental well-being through intentional psychedelic use.
Psychedelic Medicine Masterclass (Dr. Manesh Girn, 2024)
A comprehensive course designed for healthcare professionals, psychonauts, and anyone curious about the science and safe, responsible use of psychedelic medicine.

Extras

🎓 Learn More

Dr. Manesh Girn – The Psychedelic Scientist (YouTube Channel)
Engaging videos that translate complex psychedelic research into easy-to-understand content for the public.

*FDA Disclaimer: The content in this video is meant for educational purposes only. The FDA has not evaluated the statements in this video and is not intended to diagnose, treat, or cure any disease.